Below is a bibliography of Dr. Brem's journal articles and other published work. Click on the links to view the publications themselves.

Journal Articles

  1. Checklist to Assist Providers in the Management of Patients with Chronic Wounds. In press, Advances in Skin & Wound Care. R. Howell, T. Criscitelli, S. Gorenstein, B. Gillette, H. Brem. 2018.
  2. Practical Application of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Patients with Wounds. H. Brem, R. Howell, T. Criscitelli, A. Senderowicz, N. Siegart, S. Gorenstein, B. Gillette. Surgical Technology International. 2018 Mar 29; 31. pii: sti32/977.
  3. A Perioperative Approach to Treating Diabetic Foot Ulcers to Increase Limb Salvage. R.S. Howell, T. Criscitelli, J.S. Woods, B. Gillette, H. Brem, S. Gorenstein. Association of PeriOperative Registered Nurses (AORN) Journal. 2018 Apr; 107(4): 431-440.
  4. Wound Care Center of Excellence: Guide to Operative Technique for Chronic Wounds. R.S. Howell, S. Gorenstein, M. Castellano, E. Slone, J.S. Woods, B. Gillette, H. Brem, C. Brathwaite. Journal of the American College of Surgeons, 2018 Feb; 226(2): 7-8
  5. Protocol for Psychopharmacologic Management of Behavioral Health Comorbidity in Adult Patients with Diabetes and Soft Tissue Infections in a Tertiary Care Hospital Setting. A. Pinkhasov, D. Singh, B. Kashan, J. DiGregorio, T.M. Criscitelli, S. Gorenstein, H. Brem. Advances in Skin & Wound Care. 2016 Nov; 29(11): 518-52.
  6. Modalities to Treat Venous Ulcers: Compression, Surgery, and Bioengineered Tissue. L.J. Gould, G. Dosi, K. Couch, G.W. Gibbons, R.S. Howell, H. Brem, M. Tomic-Canic. Plastic and Reconstructive Surgery. 2016 Sep; 138(3 Suppl): 199S-208S.
  7. Major Histopathologic Diagnoses of Chronic Wounds. G.K. Turi, V. Donovan, J. DiGregorio, T.M. Criscitelli, B. Kashan, S. Barrientos, J.R. Balingcongan, S. Gorenstein, H. Brem. Advances in Skin & Wound Care. 2016 Aug; 29(8): 376-82.
  8. Chronic Wound Repair and Healing in Older Adults: Current Status and Future Research. L. Gould, P. Abadir, H. Brem, M. Carter, T. Conner-Kerr, J. Davidson, L. DiPietro, V. Falanga, C. Fife, S. Gardner, E. Grice, J. Harmon, W.R. Hazzard, K.P. High, P. Houghton, N. Jacobson, R.S. Kirsner, E.J. Kovacs, D. Margolis, F. McFarland Horne, M.J. Reed, D.H. Sullivan, S. Thom, M. Tomic-Canic, J. Walston, J.A. Whitney, J. Williams, S. Zieman, K. Schmader. Journal of the American Geriatrics Society. 2015 Mar; 63(3): 427-38. Wound Repair and Regeneration. 2015 Jan-Feb; 23(1): 1-13.
  9. Wounds in Patients with HIV. Alexander McMeeking, In Kim, Frank Ross, Elizabeth A. Ayello, Harold Brem, Patrick Linton, Daniel K. O’Neill. Advances in Skin & Wound Care. 2014; 27:396-403.
  10. Clinical Application of Growth Factors and Cytokines in Wound Healing. Stephan Barrientos, Harold Brem, Olivera Stojadinovic, Marjana Tomic-Canic. Wound Repair and Regeneration. 2014; 22(5):569-78.
  11. Acute Lung Injury Following the Use of Granulocyte-Macrophage Colony-Stimulating Factor. Kristina Kudlak, Jonas P. DeMuro, Adel F. Hanna, Harold Brem. International Journal of Critical Illness & Injury Science. 2013; 3(4): 279-81.
  12. Regional Anaesthesia with Sedation Protocol to Safely Debride Sacral Pressure Ulcers. Daniel K. O’Neill, Bryan Robins, Elizabeth A . Ayello, Germaine Cuff, Patrick Linton, Harold Brem. International Wound Journal, Oct. 2012; 9(5): 525-543.
  13. Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing. Irena Pastar, Aly Azeem Khan, Olivera Stojadinovic, Elizabeth A. Lebrun, Mayrin Correa Medina, Harold Brem, Robert S. Kirsner, Joaquin J. Jimenez, Christina Leslie, Marjana Tomic-Canic. Journal Of Biological Chemistry, Aug. 24, 2012; 287(35): 29324–29335.
  14. Cortisol Synthesis in eEpidermis is Induced by IL-1 and Tissue Injury. Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M. J Biol Chem. 2011; 286:10265-75.
  15. High Cost of Stage IV Pressure Ulcers. Brem H, Maggi J, Nierman D, Rolnitzky L, Bell D, Rennert R, Golinko M, Yan A, Lyder C, Vladeck B. American Journal of Surgery. 2010; 200:473-477.
  16. Attenuation of the Transforming Growth Factor β–Signaling Pathway in Chronic Venous Ulcers. Irena Pastar, Olivera Stojadinovic, Agata Krzyzanowska, Stephan Barrientos, Christina Stuelten, Karen Zimmerman, Miroslav Blumenberg, Harold Brem, Marjana Tomic-Canic. Molecular Medicine, March-April 2010; 16(3-4): 92-101.

Reviews, Books, and Chapters

  1. Maggi J, Ragupathi M, Tomic-Canic M, Brem H. Age and Impaired Healing Potential, Advances in Wound Care 2010, Volume 1: 177-186.
  2. Zimmerman K, Stojadinovic O, Lebrun E, Tomic-Canic M, Brem H. Cellular and Molecular Mechanism of Chronic Wounds Advances in Wound Care 2010, Volume 1:165-176.
  3. Maggi J, Brem H. The future of CACS in wound healing. Archives Surgery 2010; 145:266.
  4. Treadwell TA, Willis AC,  Brem H. Sickle cell ulcers. In Ayello EA, Barnoski S, eds. Wound Care Essentials: Practice Principles, Second Edition. Lippincott Williams & Wilkins, 2008; 363-372.
  5. Hanflik. A, Golinko, M, Doft, M, Cain, C, Flattau, A, Brem, HOperative Debridements of Chronic Wounds. Eds. Jeffrey H. Silverstein, G. Alec Rooke, J.G. Reves, Charles H. McLeskey. In Geriatric Anesthesiology, 2nd Edition. New York. Springer, 2007.
  6. Willis A, Gibber M, Moore S, Brem H. Sickle cell disease and leg ulcers: Pathogenesis, complications, assessment, and treatment. In Ayello EA, Baranoski S, eds. Wound Care Essentials.  Springhouse. Hagerstown, 2003.
  7. Brem H. Specific paradigm for wound bed preparation in chronic wounds. In Cherry GW, Harding KG, Ryan TJ, eds. Wound Bed Preparation. The Royal Society of Medicine Press Ltd. University of Oxford, UK. 2001; 33-39.
  8. Falanga V, Brem H. Wound bed preparation for optimal use of advanced therapeutic products. In: Falanga V, Ed. Cutaneous Wound Healing. Boston University Press, 2001; 457-468.
  9. Mineta GL, Falanga V, Brem H. Current and investigative use of Graftskin in wound care: Questions and answers. Wounds 2000;12:47A-49A.
  10. Latifi R, Rosser JC, and Brem H. Anatomy and clinical outcomes in surgery for esophageal reflux. In: R.C. Merrell, Ed: Laparoscopic Surgery: a Colloquium Springer Verlag, New York, 1999; 95-102.
  11. Latifi R, Brem H, and Rosser JC.  In search of a role for laparoscopic inguinal hernia repair. In: R.C. Merrell, Ed. Laparoscopic Surgery: A Colloquium Springer Verlag, New York, 1999; 167-179.
  12. Rosser JC, and Brem H. Technique of laparoscopic Nissen fundoplication. In: R.C. Merrell, Editor. Laparoscopic Surgery: A Colloquium. Springer Verlag, New York, 1999; 115-125
  13. Rosser JC, Latifi R, and Brem H. Pathophysiology of esophageal reflux. In: R.C. Merrell, Editor. Laparoscopic Surgery: A Colloquium. Springer Verlag, New York. 1999; 103-114.
  14. Brem H, Folkman J: Angiogenesis and basic fibroblast growth factor during wound healing. In: Bone Formation and Repair. Brighton CT, Friedlaender GE, Lane JM (eds.) American Academy of Orthopedic Surgeons Publishers. 1994; 213, 222-240.
  15. Brem H, Tamavokopulis G, Tsakayannis D, Gresser I, Budson A, Folkman J: Regulation of blood vessel growth in tumors and wounds. In: Angiogenesis, Molecular Biology, Clinical Aspects. Marajoudakis ME, Gullino PM, Lelkes PI (eds.) Plenum Press Publishers, 1994; 335-336.
  16. Brem H, Klagsbrun M: The role of fibroblast growth factors and related oncogenes in tumor growth. In: Oncogenes and Tumor Suppressor Genes in Human Malignancies. Benz CC, Liu ET, eds. Kluwer Academic Publishers: 1993; 211-31.
  17. Folkman J, Brem H: Angiogenesis and inflammation. In: Inflammation: Basic Principles and Clinical Correlates, 2nd Edition, Gallin JL, Goldstein IM, Snyderman R, eds., Raven Press, New York, NY: 1992; 821-39.
  18. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J: Synthetic analogs of fumagillin that inhibits angiogenesis and suppress tumor growth. Selected in abstract from The Yearbook of Surgery, Schwartz S, Jonasson O, Peacock EE, Shires GT, Spencer GT, Thompson JC, eds 1992.
  19. Brem H, Tamargo RJ, Guerin C, Brem SS, Brem H: Brain tumor angiogenesis. In: Advances in Neuro-oncology. Kornblith PL and Walker MD, eds. Futura Publishing Co.; 1988; 89-108.

Media Resource Educational Material

CD ROMs edited by H. Brem, MD and written by James C. Rosser, MD

  1. 1998   Laparoscopic Inguinal Hernia – Surgical Techniques
  2. 1998   Laparoscopic Inguinal Hernia – Patient Education
  3. 1998   Laparoscopic Cholecystectomy – Surgical Techniques
  4. 1998   Laparoscopic Cholecystectomy – Patient Education
  5. 1998   Laparoscopic Nissen Fundoplication – Surgical Techniques
  6. 1998   Laparoscopic Nissen Fundoplication – Patient Education


A futuristic graphics pointing by a hand
A doctor with tablet that projects a human anatomy holograph

Wound Healing Videos produced with senior author H. Brem

    1. 2009   American College of Surgeons – Surgical Deep Tissue Debridement of Pressure Ulcers: Techniques of Wound and Bone Excision in the Presence of Osteomyelitis. (American College of Surgeons)
    2. 2009  American College of Surgeons- Surgical Technique Correlating the Molecular Basis of Non-healing Venous Ulcers (American College of Surgeons)
    3. 2009   American College of Surgeons- Surgical Debridement of a Diabetic Foot Ulcer with Osteomyelitis: Cellular Basis of Healing (American College of Surgeons)
    4. 2008  American College of Surgeons – Surgical Techniques and the Importance of Wide Debridement in Diabetic Foot Ulcers, (American College of Surgeons)
    5. 2008   American College of Surgeons – Surgical Technique of Debridement for New Stage IV Pressure Ulcers, (American College of Surgeons)