Dr. Brem's
Patents and
Patent Applications
Following our model of patient-driven translational research, Dr. Harold Brem and his professional colleagues have been involved in the development of a number of new drug therapies and treatment methods for chronic wounds.
At present, the center has been granted a patent or has a pending patent application related to the following discoveries. For a full description of each, click on the title of the individual patent or patent application:
Patents Granted
U.S. Patent 6,638,949
Inventors: Judah Folkman, Harold Brem, H. Paul Ehrlich
October 28, 2003
Title: Prevention of Adhesions and Excessive Scar Formation Using Angiogenesis Inhibitors
U.S. Patent 7,919,478
Inventor: Harold Brem
April 5, 2011
Title: Method for Treating Diabetic Ulcers with Vectors Encoding VEGF
U.S. Patent 8,673,859
Inventors: Harold Brem, Marjana Tomic
March 18, 2014
Title: GM-CSF Cosmeceutical Compositions and Methods of Use Thereof
U.S. Patent 8,802,660
Inventors: Marjana Tomic-Canic, Harold Brem, Herbert H. Samuels
August 12, 2014
Title: De Novo Synthesis of Glucocorticoids in the Epidermis and Its Uses and Applications
U.S. Patent 8,889,615
Inventors: Marjana Tomic-Canic, Harold Brem
November 18, 2014
Title: Methods for Promoting Epithelialization and Healing of Chronic Wounds
U.S. Patent 9,168,214
Inventors: Harold Brem, Marjana Tomic-Canic
October 27, 2015
Title: Methods of Increasing Collagen Formation and Cellular Migration in Intact Skin
Pending Patent Applications
U.S. Patent Application 20060116904
Inventor: Harold Brem
June 1, 2006
U.S. Patent Application 20080175820
Inventor: Harold Brem
July 24, 2008
Title: Method for Treating Diabetic Ulcers
U.S. Patent Application 20090203006
Inventors: Harold Brem and Marjana Tomic-Canic
August 13, 2009
Title: Biological Markers of Chronic Wound Tissue and Methods of Using for Criteria in Surgical Debridement
U.S. Patent Application 20100310517
Inventors: Harold Brem and Marjana Tomic-Canic
December 9, 2010
Title: Growth Factor Mediated Cosmeceuticals and Use Thereof to Enhance Skin Quality
U.S. Patent Application 20110190372
Inventors: Harold Brem, and Marjana Tomic-Canic
August 4, 2011
Title: Compositions and Methods for Treating Inflammatory Disorders
U.S. Patent Application 20130090255
Inventors: Harold Brem, Marjana Tomic-Canic
April 11, 2013
Title: Biological Markers of Chronic Wound Tissue and Methods of Using for Criteria in Surgical Debridement